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The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. This incredible discovery was sulfa, the first antibiotic. In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of the drug that shaped modern medicine.
Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness.
A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel.
For thousands of years, humans had sought medicines with which they could defeat contagion, and they had slowly, painstakingly, won a few battles: some vaccines to ward off disease, a handful of antitoxins. A drug or two was available that could stop parasitic diseases once they hit, tropical maladies like malaria and sleeping sickness. But the great killers of Europe, North America, and most of Asia—pneumonia, plague, tuberculosis, diphtheria, cholera, meningitis—were caused not by parasites but by bacteria, much smaller, far different microorganisms. By 1931, nothing on earth could stop a bacterial infection once it started. . . .
But all that was about to change. . . . —from The Demon Under the Microscope
From the Hardcover edition.
- Sales Rank: #307718 in Books
- Model: 3582709
- Published on: 2007-08-28
- Released on: 2007-08-28
- Original language: English
- Number of items: 1
- Dimensions: 7.99" h x .77" w x 5.19" l, .75 pounds
- Binding: Paperback
- 352 pages
Most helpful customer reviews
0 of 0 people found the following review helpful.
A remarkably effective reminder to wash your hands. Good book, too.
By Harlan Kanoa Sheppard
This was recommended to me by a microbiology professor, and a sound recommendation it was. Briefly, I'll discuss who it appeals to and then the book itself.
To frame my interest, I'm the sort of person who likes watching "How It's Made" and am fascinated by infectious disease and the countermeasures deployed against them. An interested layperson. If you've ever taken a Microbiology course (or something related), you can likely appreciate the nuance of what's happening. Otherwise, it might seem a little nebulous.
Bookwise, we step into the ancient world. Nowadays, the germ theory of disease is not contested. It is the reality we live in. If someone gets sick and there isn't a bone poking out of somewhere, we tend to blame germs. Professionals break up germs into many different divisions and categories, but for the most part, the medical profession can do something when you get sick. Like... cure you.
It becomes clear that illness was a more grave concern as recently as a century ago, something that wasn't conceivable for me before I read this book. Wife got sick after childbirth? Bye bye, wifey. Kids got sick? Well, crap. Better have more. In this day and age where we try to save so many lives, it strains credulity to imagine that life was so cheap.
Enter Domagk, a researcher at the bleeding edge of his field. This is a tale of a man who was obsessed with locating a 'magic bullet' to do away with infection. It was a riveting read, and I'm glad to have put the time into it.
2 of 2 people found the following review helpful.
One of the best popular science books I've read
By K. Josic
This is a truly eye opening book. On the surface it describes the history of the
discovery of a synthetic antibiotic that is of limited use in modern medicine. But it
really is far more than that - it tells an important part of the story of how
the pharma and medicine that we know today came to be. Hager does not overreach -
he has a compelling story, and he tells it exceedingly well. But he also does a superb
job of putting it in both its historical and scientific context.
Nonlinear storytelling has become pretty common in modern science writing,
and it is can be pretty annoying - writers seem to selectively choose fractions
of episodes from the history that seem to support their (frequently very narrow)
thesis. In this book, Hager uses the same technique in a far more effective and
informative way. The interludes are themselves brief, but masterfully told,
histories of great discoveries in science and medicine.
0 of 0 people found the following review helpful.
Great science history read
By Fishon boston
Fantastic history of the German drug companies and early drug development. Well written ,engaging and entertaining.
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